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Compounds of this class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to canada ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.

Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by For neurotransmitter gamma-aminobutyric acid Stromectol. The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily sale the blood-brain barrier, Stromectol For Sale In Canada.

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Ivermectin is the only orally active and effective scabicidal agent which is also used in the treatment of pediculosis lice infestation. Ivermectin is supplied as oral tablets of 3 mg strength.

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